Nature Communications (Apr 2022)
A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis
- Johanne Brooks-Warburton,
- Dezso Modos,
- Padhmanand Sudhakar,
- Matthew Madgwick,
- John P. Thomas,
- Balazs Bohar,
- David Fazekas,
- Azedine Zoufir,
- Orsolya Kapuy,
- Mate Szalay-Beko,
- Bram Verstockt,
- Lindsay J. Hall,
- Alastair Watson,
- Mark Tremelling,
- Miles Parkes,
- Severine Vermeire,
- Andreas Bender,
- Simon R. Carding,
- Tamas Korcsmaros
Affiliations
- Johanne Brooks-Warburton
- Earlham Institute, Norwich Research Park
- Dezso Modos
- Earlham Institute, Norwich Research Park
- Padhmanand Sudhakar
- Earlham Institute, Norwich Research Park
- Matthew Madgwick
- Earlham Institute, Norwich Research Park
- John P. Thomas
- Earlham Institute, Norwich Research Park
- Balazs Bohar
- Earlham Institute, Norwich Research Park
- David Fazekas
- Earlham Institute, Norwich Research Park
- Azedine Zoufir
- Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge
- Orsolya Kapuy
- Department of Molecular Biology, Semmelweis University
- Mate Szalay-Beko
- Earlham Institute, Norwich Research Park
- Bram Verstockt
- KU Leuven, Department of Chronic diseases, Metabolism and Ageing
- Lindsay J. Hall
- Gut Microbes and Health Programme, The Quadram Institute Bioscience, Norwich Research Park
- Alastair Watson
- Department of Gastroenterology, Norfolk and Norwich University Hospitals
- Mark Tremelling
- Department of Gastroenterology, Norfolk and Norwich University Hospitals
- Miles Parkes
- Inflammatory Bowel Disease Research Group, Addenbrooke’s Hospital, University of Cambridge
- Severine Vermeire
- KU Leuven, Department of Chronic diseases, Metabolism and Ageing
- Andreas Bender
- Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge
- Simon R. Carding
- Gut Microbes and Health Programme, The Quadram Institute Bioscience, Norwich Research Park
- Tamas Korcsmaros
- Earlham Institute, Norwich Research Park
- DOI
- https://doi.org/10.1038/s41467-022-29998-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Single Nucleotide Polymorphisms (SNPs) affect cellular regulatory networks, and SNP co-occurrences contribute to disease pathogenesis in ulcerative colitis (UC). Here the authors introduce iSNP, a precision medicine pipeline that combines genomics and network biology approaches to uncover patient specific pathways affected in complex diseases.
