DISSOLUTION PROFILE STUDIES FOR RAMIPRIL AND LERCANIDIPINE FIXED-DOSE COMBINATION

Abstract

This article describes the results of the development of composition and technology of a combined drug, containing lercanidipine and ramipril, affording equivalent dissolution kinetics with original drugs. The comparative release profiles of the active pharmaceutical ingredients are shown. The choice of a solid dosage form in the form of bi-layer tablets was substantiated.

Keywords

• ramipril
• lercanidipine
• bi-layer tablets
• dissolution kinetics