Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal

Hui-Ju Tsai; Chia-Fang Wu; Chao A. Hsiung; Chieng-Hung Lee; Shu-Li Wang; Mei-Lien Chen; Chu-Chih Chen; Po-Chin Huang; Yin-Han Wang; Yuh-An Chen; Bai-Hsiun Chen; Yun-Shiuan Chuang; Hui-Min Hsieh; Ming-Tsang Wu

Environment International (Jan 2022)

Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal

Hui-Ju Tsai,
Chia-Fang Wu,
Chao A. Hsiung,
Chieng-Hung Lee,
Shu-Li Wang,
Mei-Lien Chen,
Chu-Chih Chen,
Po-Chin Huang,
Yin-Han Wang,
Yuh-An Chen,
Bai-Hsiun Chen,
Yun-Shiuan Chuang,
Hui-Min Hsieh,
Ming-Tsang Wu

Affiliations

Hui-Ju Tsai: Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Chia-Fang Wu: Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; International Master Program of Translational Medicine, National United University, Miaoli, Taiwan
Chao A. Hsiung: Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Chieng-Hung Lee: Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
Shu-Li Wang: Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Mei-Lien Chen: Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Chu-Chih Chen: Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Po-Chin Huang: Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Yin-Han Wang: Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Yuh-An Chen: Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Bai-Hsiun Chen: Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine and Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Yun-Shiuan Chuang: Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Hui-Min Hsieh: Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
Ming-Tsang Wu: Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; PhD Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Rapid Screening Research Center for Toxicology and Biomedicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; Corresponding author at: Department of Family Medicine & Department of Public Health, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Room 721, CS Building, No.100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan.

Journal volume & issue: Vol. 158
p. 107018

Abstract

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In 2011, phthalates, mainly di-(2-ethylhexyl) phthalate (DEHP), were found to have been added to a variety of foods in Taiwan, increasing the risk of microalbuminuria in children. Exposure to melamine perhaps modifies that risk. This prospective cohort study investigates whether renal injury resulting from exposure to DEHP-tainted foods from the 2011 Taiwan Food Scandal is reversed over time. The temporal and interactive effects of past daily DEHP intake, current daily DEHP intake, and urinary melamine levels on oxidative stress and renal injury were also examined.Two hundred possibly DEHP-affected children (aged 50 μg/kg/day). Urinary melamine levels were found to correlate significantly with both urinary ACR and oxidative stress markers. The highest impact associated with exposure to DEHP-tainted foods in increasing urinary ACR of children was observed during the first wave, and the effect may partially diminish over time. These results suggest that continuous monitoring of renal health and other long-term health consequences is required in individuals who were affected by the scandal in 2011.

Published in Environment International

ISSN: 0160-4120 (Print)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environment-international

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