The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump

Abstract

Francesca Short et al. identify natural polyamines as substrates for a drug efflux pump in the clinically-relevant pathogen, Acinetobacter baumannii. Their results suggest that efflux pumps now known to be involved in drug resistance may have originated as polyamine transporters.