Vitamin D deficiency and VDR gene polymorphism FokI (rs2228570) are associated with diabetes mellitus in adults: COVID-inconfidentes study

Abstract

Highlights The prevalence of vitamin D deficiency was higher in patients with diabetes mellitus; The FokI polymorphism was associated with DM and, in synergism with vitamin D deficiency, increased the likelihood of DM in adults. The FokI polymorphism was the most frequent in individuals with diabetes; Individuals with VDD were more predisposed to have DM regardless of phenotype, meaning that vitamin D deficiency is a relevant predictor for developing DM, regardless of whether or not there is an alteration in the VDR receptor.

Keywords

• Single-nucleotide polymorphism
• Vitamin D receptor
• Population Genetics
• Diabetes
• Glycated hemoglobin