A study of association of uric acid with the development of gestational diabetes mellitus

Abstract

Objectives: To evaluate the value of serum uric acid in early pregnancy to predict the development of gestational diabetes mellitus (GDM). Methods: This prospective observational cohort study included 336 women in their first trimester of pregnancy (3.5 mg/dl in 54 (16.07%) participants. The prevalence of GDM was 27(7.71%) among which 24 cases had higher serum uric acid. Higher age carried a significantly higher odds of occurrence of GDM with odds ratio of 8.125 (P=0.0004). Presence of higher-risk factors and increased uric acid carried significantly higher odds of 11.722 and 74.4, respectively for occurrence of GDM (P3.5 carried a sensitivity of 88.9% and specificity of 90.3% for predicting GDM. Conclusion: Antenatal women without the known high-risk factors of DM developed GDM when the serum uric acid level was > 3.5 mg/dl. In conclusion, higher serum uric acid levels in the early pregnancy can serve as a novel marker for predicting the development of GDM.

Keywords

• first trimester
• fetomaternal complications
• gestational diabetes mellitus
• uric acid