P417: A SINGLE AMINO ACID AT THE PNT DOMAIN OF ERG MEDIATES ITS LEUKEMOGENIC ACTIVITY THROUGH INTERACTION WITH THE NCOR-HDAC3 CO-REPRESSOR COMPLEX.

• E. Kugler,
• S. Madiwale,
• D. Yong,
• Y. Birger,
• J. A. I. Thoms,
• D. B. Sykes,
• M. Yassin,
• N. Aqaqe,
• A. Rein,
• H. Fishman,
• I. Geron,
• C.-W. Chen,
• B. Raught,
• Q. Liu,
• M. Milyavsky,
• J. Pimanda,
• G. G. Privé,
• S. Izraeli

Affiliations

E. Kugler

1 Institute of Hematology, Davidoff Cancer Center, Rabin medical center, Petah Tikva

S. Madiwale

2 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

D. Yong

3 Department of Biochemistry, University of Toronto, Toronto, Canada

Y. Birger

2 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

J. A. I. Thoms

5 Adult Cancer Program, Lowy Cancer Research Centre

D. B. Sykes

7 Center for Regenerative Medicine, Massachusetts General Hospital, Boston

M. Yassin

9 Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

N. Aqaqe

9 Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

A. Rein

2 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

H. Fishman

2 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

I. Geron

2 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel

C.-W. Chen

10 Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte

B. Raught

13 Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

Q. Liu

10 Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte

M. Milyavsky

9 Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

J. Pimanda

5 Adult Cancer Program, Lowy Cancer Research Centre

G. G. Privé

3 Department of Biochemistry, University of Toronto, Toronto, Canada

S. Izraeli

2 Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel