Nature Communications (May 2022)
WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour
- Shiu-Ling Chen,
- Bo-Ting Liu,
- Wang-Pao Lee,
- Sin-Bo Liao,
- Yao-Bang Deng,
- Chia-Lin Wu,
- Shuk-Man Ho,
- Bing-Xian Shen,
- Guan-Hock Khoo,
- Wei-Chiang Shiu,
- Chih-Hsuan Chang,
- Hui-Wen Shih,
- Jung-Kun Wen,
- Tsuo-Hung Lan,
- Chih-Chien Lin,
- Yu-Chen Tsai,
- Huey-Fen Tzeng,
- Tsai-Feng Fu
Affiliations
- Shiu-Ling Chen
- Department of Applied Chemistry, National Chi Nan University
- Bo-Ting Liu
- Department of Applied Chemistry, National Chi Nan University
- Wang-Pao Lee
- Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University
- Sin-Bo Liao
- Department of Applied Chemistry, National Chi Nan University
- Yao-Bang Deng
- Department of Applied Chemistry, National Chi Nan University
- Chia-Lin Wu
- Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University
- Shuk-Man Ho
- Department of Applied Chemistry, National Chi Nan University
- Bing-Xian Shen
- Department of Applied Chemistry, National Chi Nan University
- Guan-Hock Khoo
- Department of Life Science and Life Science Center, Tunghai University
- Wei-Chiang Shiu
- Department of Applied Chemistry, National Chi Nan University
- Chih-Hsuan Chang
- Department of Life Science and Life Science Center, Tunghai University
- Hui-Wen Shih
- Department of Life Science and Life Science Center, Tunghai University
- Jung-Kun Wen
- Institute of Biological Chemistry, Academia Sinica
- Tsuo-Hung Lan
- Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University
- Chih-Chien Lin
- Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University
- Yu-Chen Tsai
- Department of Life Science and Life Science Center, Tunghai University
- Huey-Fen Tzeng
- Department of Applied Chemistry, National Chi Nan University
- Tsai-Feng Fu
- Department of Applied Chemistry, National Chi Nan University
- DOI
- https://doi.org/10.1038/s41467-022-30165-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The authors show that the Drosophila master regulator WAKE modulates the secretion of insulin-like peptides, triggering a decrease in 20-hydroxyecdysone levels. This lowers the perception of a male-specific sex pheromone and explains why WAKE-deficient Drosophila flies show male-male courtship behaviour.
