PLoS ONE (Jan 2015)

Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort.

  • Gaetane Nocturne,
  • Stephan Pavy,
  • Saida Boudaoud,
  • Raphaèle Seror,
  • Philippe Goupille,
  • Philippe Chanson,
  • Désirée van der Heijde,
  • Floris van Gaalen,
  • Francis Berenbaum,
  • Xavier Mariette,
  • Karine Briot,
  • Antoine Feydy,
  • Pascal Claudepierre,
  • Philippe Dieudé,
  • Joanne Nithitham,
  • Kimberly E Taylor,
  • Lindsey A Criswell,
  • Maxime Dougados,
  • Christian Roux,
  • Corinne Miceli-Richard

DOI
https://doi.org/10.1371/journal.pone.0134974
Journal volume & issue
Vol. 10, no. 8
p. e0134974

Abstract

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To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 serum levels were higher in axial SpA patients than controls (30.03 ± 15.5 vs. 11.6 ± 4.2 pmol/L; p<0.0001). In multivariate analysis, DKK-1 serum levels were associated with male gender (p = 0.03), CRP level (p = 0.006), SOST serum level (p = 0.002) and presence of sacroiliitis on radiography (p = 0.05). Genetic association testing of 10 SNPs encompassing the DKK-1 locus failed to demonstrate a significant contribution of genetics to control of DKK-1 serum levels.DKK-1 serum levels were increased and SOST levels were decreased among a large cohort of patients with early axial SpA compared to healthy controls. DKK-1 serum levels were mostly associated with biological inflammation and SOST serum levels.