TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms

Nan Xu; Yufeng He; Chunyu Zhang; Yongqiang Zhang; Shengjie Cheng; Li Deng; Yi Zhong; Bin Liao; Yan Wei; Jian Feng

Neurobiology of Disease (Mar 2024)

TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms

Nan Xu,
Yufeng He,
Chunyu Zhang,
Yongqiang Zhang,
Shengjie Cheng,
Li Deng,
Yi Zhong,
Bin Liao,
Yan Wei,
Jian Feng

Affiliations

Nan Xu: Department of Cardiology, The First People's Hospital of Neijiang, Neijiang, China
Yufeng He: Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Chunyu Zhang: Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Yongqiang Zhang: Department of Cardiology, Hejiang County People's Hospital, Luzhou, China
Shengjie Cheng: Department of Cardiology, The First People's Hospital of Neijiang, Neijiang, China
Li Deng: Department of Rheumatology, The Afliated Hospital of Southwest Medical University, Luzhou, China
Yi Zhong: Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Bin Liao: Department of Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, China
Yan Wei: Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China; Corresponding authors.
Jian Feng: Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China; Corresponding authors.

Journal volume & issue: Vol. 192
p. 106428

Abstract

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The heart and brain are the core organs of the circulation and central nervous system, respectively, and play an important role in maintaining normal physiological functions. Early neuronal and cardiac damage affects organ function. The relationship between the heart and brain is being continuously investigated. Evidence-based medicine has revealed the concept of the “heart- brain axis,” which may provide new therapeutic strategies for certain diseases. Takeda protein-coupled receptor 5 (TGR5) is a metabolic regulator involved in energy homeostasis, bile acid homeostasis, and glucose and lipid metabolism. Inflammation is critical for the development and regeneration of the heart and brain during metabolic diseases. Herein, we discuss the role of TGR5 as a metabolic regulator of heart and brain development and injury to facilitate new therapeutic strategies for metabolic and ischemic diseases of the heart and brain.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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