Increased Expression and Redistribution of the Antiapoptotic Molecule Bcl-xL in Parkinson's Disease

Abstract

In the present study, we tried to clarify the potentially protective role of Bcl-xL, an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we show that in PD patients Bcl-xL mRNA expression per dopaminergic neuron was almost double that of controls. We also show that, ultrastructurally, this effect may be mediated by a redistribution of Bcl-xL from the cytosol to the outer mitochondrial membrane.

Keywords

• Parkinson's disease
• apoptosis
• mitochondria
• Bcl-xL