eLife (Feb 2019)
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
- Maria C Marchetto,
- Branka Hrvoj-Mihic,
- Bilal E Kerman,
- Diana X Yu,
- Krishna C Vadodaria,
- Sara B Linker,
- Iñigo Narvaiza,
- Renata Santos,
- Ahmet M Denli,
- Ana PD Mendes,
- Ruth Oefner,
- Jonathan Cook,
- Lauren McHenry,
- Jaeson M Grasmick,
- Kelly Heard,
- Callie Fredlender,
- Lynne Randolph-Moore,
- Rijul Kshirsagar,
- Rea Xenitopoulos,
- Grace Chou,
- Nasun Hah,
- Alysson R Muotri,
- Krishnan Padmanabhan,
- Katerina Semendeferi,
- Fred H Gage
Affiliations
- Maria C Marchetto
- ORCiD
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Branka Hrvoj-Mihic
- Department of Anthropology, University of California, San Diego, La Jolla, United States
- Bilal E Kerman
- ORCiD
- Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey
- Diana X Yu
- Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, United States
- Krishna C Vadodaria
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Sara B Linker
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Iñigo Narvaiza
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Renata Santos
- ORCiD
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States; Laboratory of Dynamic of Neuronal Structure in Health and Disease, Institute of Psychiatry and Neuroscience of Paris (UMR S894 INSERM, University Paris Descartes), Paris, France
- Ahmet M Denli
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Ana PD Mendes
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Ruth Oefner
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Jonathan Cook
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Lauren McHenry
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Jaeson M Grasmick
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Kelly Heard
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Callie Fredlender
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Lynne Randolph-Moore
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Rijul Kshirsagar
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Rea Xenitopoulos
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Grace Chou
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Nasun Hah
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- Alysson R Muotri
- Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, United States; Department of Cellular & Molecular Medicine, Rady Children's Hospital San Diego, La Jolla, United States
- Krishnan Padmanabhan
- Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, United States
- Katerina Semendeferi
- Department of Anthropology, University of California, San Diego, La Jolla, United States; Neuroscience Graduate Program, University of California San Diego, La Jolla, United States
- Fred H Gage
- ORCiD
- Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, United States
- DOI
- https://doi.org/10.7554/eLife.37527
- Journal volume & issue
-
Vol. 8
Abstract
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex. Our results show differential migration patterns in human neural progenitor cells compared to those of chimpanzees and bonobos both in vitro and in vivo, suggesting heterochronic changes in human neurons. The strategy proposed here lays the groundwork for further comparative analyses between humans and NHPs and opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species.
Keywords
