Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient

Abstract

A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically distinct. Transmitted infection with mixed strains is likely underappreciated; identifying these infections requires spoligotyping and whole-genome sequencing.

Keywords

• heteroresistance
• whole genome sequencing
• spoligotyping
• Mycobacterium tuberculosis
• bacteria
• drug resistance