Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Jinhong Chen; Zhichao Liu; Li Ma; Shengwei Gao; Huanjie Fu; Can Wang; Anmin Lu; Baohe Wang; Xufang Gu

doi:10.3389/fgene.2021.780649

Frontiers in Genetics (Dec 2021)

Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Jinhong Chen,
Zhichao Liu,
Li Ma,
Shengwei Gao,
Huanjie Fu,
Can Wang,
Anmin Lu,
Baohe Wang,
Xufang Gu

Affiliations

Jinhong Chen: Department of TCM, Tianjin University of TCM, Tianjin, China
Zhichao Liu: Department of TCM, Tianjin University of TCM, Tianjin, China
Li Ma: Department of TCM, Tianjin University of TCM, Tianjin, China
Shengwei Gao: Department of TCM, Tianjin University of TCM, Tianjin, China
Huanjie Fu: Department of TCM, Tianjin University of TCM, Tianjin, China
Can Wang: Acupuncture Department, The First Affiliated Hospital of Tianjin University of TCM, Tianjin, China
Anmin Lu: Department of TCM, Tianjin University of TCM, Tianjin, China
Baohe Wang: Department of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China
Xufang Gu: Department of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China

DOI: https://doi.org/10.3389/fgene.2021.780649
Journal volume & issue: Vol. 12

Abstract

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Myocardial infarction (MI) is a complicated pathology triggered by numerous environmental and genetic factors. Understanding the effect of epigenetic regulation mechanisms on the cardiovascular disease would advance the field and promote prophylactic methods targeting epigenetic mechanisms. Genetic screening guides individualised MI therapies and surveillance. The present review reported the latest development on the epigenetic regulation of MI in terms of DNA methylation, histone modifications, and microRNA-dependent MI mechanisms and the novel therapies based on epigenetics.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

About the journal

Abstract

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