Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

Melissa A. Meyer; John M. Baer; Brett L. Knolhoff; Timothy M. Nywening; Roheena Z. Panni; Xinming Su; Katherine N. Weilbaecher; William G. Hawkins; Cynthia Ma; Ryan C. Fields; David C. Linehan; Grant A. Challen; Roberta Faccio; Rebecca L. Aft; David G. DeNardo

doi:10.1038/s41467-018-03600-6

Nature Communications (Mar 2018)

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

Melissa A. Meyer,
John M. Baer,
Brett L. Knolhoff,
Timothy M. Nywening,
Roheena Z. Panni,
Xinming Su,
Katherine N. Weilbaecher,
William G. Hawkins,
Cynthia Ma,
Ryan C. Fields,
David C. Linehan,
Grant A. Challen,
Roberta Faccio,
Rebecca L. Aft,
David G. DeNardo

Affiliations

Melissa A. Meyer: Department of Medicine, Washington University School of Medicine
John M. Baer: Department of Medicine, Washington University School of Medicine
Brett L. Knolhoff: Department of Medicine, Washington University School of Medicine
Timothy M. Nywening: Department of Surgery, Washington University School of Medicine
Roheena Z. Panni: Department of Medicine, Washington University School of Medicine
Xinming Su: Department of Medicine, Washington University School of Medicine
Katherine N. Weilbaecher: Department of Medicine, Washington University School of Medicine
William G. Hawkins: Department of Surgery, Washington University School of Medicine
Cynthia Ma: Department of Medicine, Washington University School of Medicine
Ryan C. Fields: Department of Surgery, Washington University School of Medicine
David C. Linehan: Department of Surgery, University of Rochester Medical Center
Grant A. Challen: Department of Medicine, Washington University School of Medicine
Roberta Faccio: Department of Orthopedic Surgery, Washington University School of Medicine
Rebecca L. Aft: Department of Surgery, Washington University School of Medicine
David G. DeNardo: Department of Medicine, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-03600-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 19

Abstract

Read online

Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal