A Multimethodological Characterization of <i>Cannabis sativa</i> L. Inflorescences from Seven Dioecious Cultivars Grown in Italy: The Effect of Different Harvesting Stages
Mattia Spano,
Giacomo Di Matteo,
Cinzia Ingallina,
Bruno Botta,
Deborah Quaglio,
Francesca Ghirga,
Silvia Balducci,
Silvia Cammarone,
Enio Campiglia,
Anna Maria Giusti,
Giuliana Vinci,
Mattia Rapa,
Salvatore Ciano,
Luisa Mannina,
Anatoly P. Sobolev
Affiliations
Mattia Spano
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Giacomo Di Matteo
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Cinzia Ingallina
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Bruno Botta
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Deborah Quaglio
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Francesca Ghirga
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Silvia Balducci
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Silvia Cammarone
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Enio Campiglia
Department of Agricultural and Forest Sciences, University of Tuscia, Via San Camillo de Lellis snc, 01100 Viterbo, Italy
Anna Maria Giusti
Department of Experimental Medicine, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Giuliana Vinci
Department of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy
Mattia Rapa
Department of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy
Salvatore Ciano
Department of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy
Luisa Mannina
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Anatoly P. Sobolev
Institute for Biological Systems, Magnetic Resonance Laboratory “Segre-Capitani”, CNR, Via Salaria Km 29.300, 00015 Monterotondo, Italy
The chemical profile of the female inflorescence extracts from seven Cannabis sativa L. dioecious cultivars (Carmagnola, Fibranova, Eletta Campana, Antal, Tiborszallasi, Kompolti, and Tisza) was monitored at three harvesting stages (4, 14, and 30 September), reaching from the beginning of flowering to end of flowering/beginning of seed formation, using untargeted nuclear magnetic resonance (NMR) and targeted (ultra-high-performance liquid chromatography (UHPLC) and spectrophotometry) analyses. The tetrahydrocannabinol content was always below the legal limits (Cannabis sativa L. inflorescences of each analyzed dioecious hemp cultivar presented a peculiar chemical profile affected by the harvesting stage. This information could be useful for producers and industries to harvest inflorescences in the appropriate stage to obtain samples with a peculiar chemical profile suitable for proper applications.
