A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite

Luling Wu; Xue Tian; Hai‐Hao Han; Jie Wang; Robin R. Groleau; Paramabhorn Tosuwan; Dr. Boontana Wannalerse; Dr. Adam C. Sedgwick; Prof. Steven D. Bull; Prof. Xiao‐Peng He; Prof. Tony D. James

doi:10.1002/open.201900301

ChemistryOpen (Dec 2019)

A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite

Luling Wu,
Xue Tian,
Hai‐Hao Han,
Jie Wang,
Robin R. Groleau,
Paramabhorn Tosuwan,
Dr. Boontana Wannalerse,
Dr. Adam C. Sedgwick,
Prof. Steven D. Bull,
Prof. Xiao‐Peng He,
Prof. Tony D. James

Affiliations

Luling Wu: Department of Chemistry University of Bath, BA2 7AY, UK
Xue Tian: Department of Chemistry University of Bath, BA2 7AY, UK
Hai‐Hao Han: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering East China University of Science and Technology 130 Meilong Rd. Shanghai 200237 China
Jie Wang: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering East China University of Science and Technology 130 Meilong Rd. Shanghai 200237 China
Robin R. Groleau: Department of Chemistry University of Bath, BA2 7AY, UK
Paramabhorn Tosuwan: Paramabhorn Tosuwan and Boontana Wannalerse Department of Chemistry, Facultry of Science Kasetsart University Bangkok 10900 Thailand
Dr. Boontana Wannalerse: Paramabhorn Tosuwan and Boontana Wannalerse Department of Chemistry, Facultry of Science Kasetsart University Bangkok 10900 Thailand
Dr. Adam C. Sedgwick: Department of Chemistry University of Texas at Austin 105 E 24th street A5300 Autin TX 78712–1224 USA
Prof. Steven D. Bull: Department of Chemistry University of Bath, BA2 7AY, UK
Prof. Xiao‐Peng He: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering East China University of Science and Technology 130 Meilong Rd. Shanghai 200237 China
Prof. Tony D. James: Department of Chemistry University of Bath, BA2 7AY, UK

DOI: https://doi.org/10.1002/open.201900301
Journal volume & issue: Vol. 8, no. 12
pp. 1407 – 1409

Abstract

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Abstract Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO− over other reactive oxygen species, including H2O2. Moreover, DCM‐Bpin is biocompatible and has been used to visualize exogenous ONOO− in HeLa cells.

Published in ChemistryOpen

ISSN: 2191-1363 (Online)
Publisher: Wiley-VCH
Country of publisher: Germany
LCC subjects: Science: Chemistry
Website: https://chemistry-europe.onlinelibrary.wiley.com/journal/21911363

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