Nature Communications (May 2022)
Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants
- Milja Belik,
- Pinja Jalkanen,
- Rickard Lundberg,
- Arttu Reinholm,
- Larissa Laine,
- Elina Väisänen,
- Marika Skön,
- Paula A. Tähtinen,
- Lauri Ivaska,
- Sari H. Pakkanen,
- Hanni K. Häkkinen,
- Eeva Ortamo,
- Arja Pasternack,
- Mikael A. Ritvos,
- Rauno A. Naves,
- Simo Miettinen,
- Tarja Sironen,
- Olli Vapalahti,
- Olli Ritvos,
- Pamela Österlund,
- Anu Kantele,
- Johanna Lempainen,
- Laura Kakkola,
- Pekka Kolehmainen,
- Ilkka Julkunen
Affiliations
- Milja Belik
- Institute of Biomedicine, University of Turku
- Pinja Jalkanen
- Institute of Biomedicine, University of Turku
- Rickard Lundberg
- Institute of Biomedicine, University of Turku
- Arttu Reinholm
- Institute of Biomedicine, University of Turku
- Larissa Laine
- Finnish Institute for Health and Welfare
- Elina Väisänen
- Institute of Biomedicine, University of Turku
- Marika Skön
- Finnish Institute for Health and Welfare
- Paula A. Tähtinen
- Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku
- Lauri Ivaska
- Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku
- Sari H. Pakkanen
- Department of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of Helsinki
- Hanni K. Häkkinen
- Department of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of Helsinki
- Eeva Ortamo
- Department of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of Helsinki
- Arja Pasternack
- Department of Physiology, University of Helsinki
- Mikael A. Ritvos
- Department of Physiology, University of Helsinki
- Rauno A. Naves
- Department of Physiology, University of Helsinki
- Simo Miettinen
- Department of Virology, University of Helsinki and HUSLAB
- Tarja Sironen
- Department of Virology, University of Helsinki and HUSLAB
- Olli Vapalahti
- Department of Virology, University of Helsinki and HUSLAB
- Olli Ritvos
- Department of Physiology, University of Helsinki
- Pamela Österlund
- Finnish Institute for Health and Welfare
- Anu Kantele
- Department of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of Helsinki
- Johanna Lempainen
- Institute of Biomedicine, University of Turku
- Laura Kakkola
- Institute of Biomedicine, University of Turku
- Pekka Kolehmainen
- Institute of Biomedicine, University of Turku
- Ilkka Julkunen
- Institute of Biomedicine, University of Turku
- DOI
- https://doi.org/10.1038/s41467-022-30162-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Vaccination shows efficacy in protecting from COVID-19, but regime and dosing optimization is still ongoing. Here the authors show that BNT162b2, mRNA-1273, or their combination with ChAdOx1 induces similar antibody responses, and those receiving three doses of BNT162b2 induce neutralizing antibodies against the Omicron variant.
