Successful Treatment of Aortic Endocarditis by <i>Achromobacter xylosoxidans</i> with Cefiderocol Combination Therapy in a Non-Hodgkin Lymphoma Patient: Case Report and Literature Review
Gianfranco La Bella,
Francesco Salvato,
Graziano Antonio Minafra,
Irene Francesca Bottalico,
Tiziana Rollo,
Lucia Barbera,
Samantha De Tullio,
Gaetano Corso,
Sergio Lo Caputo,
Rosella De Nittis,
Fabio Arena
Affiliations
Gianfranco La Bella
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Francesco Salvato
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Graziano Antonio Minafra
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Irene Francesca Bottalico
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Tiziana Rollo
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Lucia Barbera
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Samantha De Tullio
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Gaetano Corso
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Sergio Lo Caputo
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Rosella De Nittis
AOU Policlinico “Riuniti”, 71121 Foggia, Italy
Fabio Arena
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Achromobacter xylosoxidans is a Gram-negative aerobic opportunistic bacterium, belonging to the order of Burkholderiales, that can cause infections of virtually all body districts in patients with underlying diseases. However, A. xylosoxidans has rarely been associated with infective endocarditis. The treatment of A. xylosoxidans infections is complicated by both intrinsic and acquired resistance. Here we report on a case of aortic endocarditis by A. xylosoxidans in a Non-Hodgkin lymphoma patient treated with a combination of cefiderocol and other antibiotics, and summarize the available literature.
