Lung transplantation following prior cardiac surgical procedures
Shane S. Scott, PhD, MS,
Doug A. Gouchoe, MD,
Divyaam Satija, BS,
Justin P. Rosenheck, DO,
Matthew C. Henn, MD, MS,
Nahush A. Mokadam, MD,
Bryan A. Whitson, MD, PhD,
Verai Ramsammy, MD,
David R. Nunley, MD,
Sakima A. Smith, MD, MPH,
Asvin M. Ganapathi, MD
Affiliations
Shane S. Scott, PhD, MS
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio
Doug A. Gouchoe, MD
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio
Divyaam Satija, BS
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio
Justin P. Rosenheck, DO
Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio
Matthew C. Henn, MD, MS
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio
Nahush A. Mokadam, MD
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio
Bryan A. Whitson, MD, PhD
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio
Verai Ramsammy, MD
Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio
David R. Nunley, MD
Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio
Sakima A. Smith, MD, MPH
Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio; Department of Medicine, Division Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio
Asvin M. Ganapathi, MD
Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio; Corresponding author: Asvin M. Ganapathi, MD, Division of Cardiac Surgery, The Ohio State University Medical Center, N-809 Doan Hall, 410 W 10th Ave, Columbus, OH 43210.
Background: As lung transplant candidates are older with increased comorbidities, we sought to examine the prevalence and outcomes of lung transplant recipients after prior cardiac surgery. Methods: Lung transplants were identified from the United Network for Organ Sharing/Organ Procurement and Transplantation Network Database. Patients were stratified based on prior cardiac surgery (no surgery [NS], prior coronary artery bypass grafting [CABG], prior valve [Valve]). Unadjusted comparisons were performed among all groups, and propensity matching was utilized for adjusted comparisons. Survival was examined with Kaplan-Meier methods. Results: A total of 28,710 patients were identified, 467 (1.6%) had prior CABG and 84 (0.3%) had prior valvular surgery. Before matching, the NS group was significantly younger, less commonly male, and had lower lung allocation scores. There were significantly fewer bilateral lung transplants in the CABG and Valve groups. Length of stay was shortest in the CABG group, but there were no significant differences in postoperative stroke, dialysis, or in-hospital mortality. There was an increased incidence of cardiac/cerebrovascular cause of death in CABG recipients (18.3%) and malignancy death in Valve recipients (23.3%). Following matching, CABG 5-year survival was lower than NS (p < 0.01), while there was no significant difference between NS and Valve groups (p = 0.4). Conclusions: CABG and Valve recipients had decreased survival, however not at levels prohibitive to transplantation. Due to potentially increased risk of cardiovascular mortality, providers should evaluate the burden of vascular disease in potential recipients with prior CABG to improve patient selection and maximize post-transplant survival.
