Nature Communications (Apr 2024)
Enhancing NSCLC recurrence prediction with PET/CT habitat imaging, ctDNA, and integrative radiogenomics-blood insights
- Sheeba J. Sujit,
- Muhammad Aminu,
- Tatiana V. Karpinets,
- Pingjun Chen,
- Maliazurina B. Saad,
- Morteza Salehjahromi,
- John D. Boom,
- Mohamed Qayati,
- James M. George,
- Haley Allen,
- Mara B. Antonoff,
- Lingzhi Hong,
- Xin Hu,
- Simon Heeke,
- Hai T. Tran,
- Xiuning Le,
- Yasir Y. Elamin,
- Mehmet Altan,
- Natalie I. Vokes,
- Ajay Sheshadri,
- Julie Lin,
- Jianhua Zhang,
- Yang Lu,
- Carmen Behrens,
- Myrna C. B. Godoy,
- Carol C. Wu,
- Joe Y. Chang,
- Caroline Chung,
- David A. Jaffray,
- Ignacio I. Wistuba,
- J. Jack Lee,
- Ara A. Vaporciyan,
- Don L. Gibbons,
- John Heymach,
- Jianjun Zhang,
- Tina Cascone,
- Jia Wu
Affiliations
- Sheeba J. Sujit
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Muhammad Aminu
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Tatiana V. Karpinets
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Pingjun Chen
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Maliazurina B. Saad
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Morteza Salehjahromi
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- John D. Boom
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Mohamed Qayati
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- James M. George
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Haley Allen
- Natural Sciences, Rice University
- Mara B. Antonoff
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Lingzhi Hong
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Xin Hu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Simon Heeke
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Hai T. Tran
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xiuning Le
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Yasir Y. Elamin
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Mehmet Altan
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Natalie I. Vokes
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Ajay Sheshadri
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Julie Lin
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Yang Lu
- Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center
- Carmen Behrens
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Myrna C. B. Godoy
- Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center
- Carol C. Wu
- Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center
- Joe Y. Chang
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Caroline Chung
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- David A. Jaffray
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- J. Jack Lee
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Ara A. Vaporciyan
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- John Heymach
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jianjun Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Tina Cascone
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jia Wu
- Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-024-47512-0
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 14
Abstract
Abstract While we recognize the prognostic importance of clinicopathological measures and circulating tumor DNA (ctDNA), the independent contribution of quantitative image markers to prognosis in non-small cell lung cancer (NSCLC) remains underexplored. In our multi-institutional study of 394 NSCLC patients, we utilize pre-treatment computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to establish a habitat imaging framework for assessing regional heterogeneity within individual tumors. This framework identifies three PET/CT subtypes, which maintain prognostic value after adjusting for clinicopathologic risk factors including tumor volume. Additionally, these subtypes complement ctDNA in predicting disease recurrence. Radiogenomics analysis unveil the molecular underpinnings of these imaging subtypes, highlighting downregulation in interferon alpha and gamma pathways in the high-risk subtype. In summary, our study demonstrates that these habitat imaging subtypes effectively stratify NSCLC patients based on their risk levels for disease recurrence after initial curative surgery or radiotherapy, providing valuable insights for personalized treatment approaches.
