Frontiers in Oncology (Feb 2020)

Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma

  • Anne Sophie Kubasch,
  • Georg-Nikolaus Franke,
  • Ali Aldaoud,
  • Konstantin Weibl,
  • Madlen Jentzsch,
  • Osama Sabri,
  • Hans-Peter Horny,
  • Falko Fend,
  • Gerhard Behre,
  • Uwe Platzbecker,
  • Vladan Vucinic

DOI
https://doi.org/10.3389/fonc.2020.00219
Journal volume & issue
Vol. 10

Abstract

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Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here presented first report about successful allogeneic hematopoietic stem cell transplantation leading to remission in a case of tonsillar MCS represents a promising potential curative treatment option for this rare and often fatal disease.

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