Frontiers in Cell and Developmental Biology (Mar 2022)
Lipid Metabolic Process Involved in Oocyte Maturation During Folliculogenesis
- Tao Liu,
- Tao Liu,
- Tao Liu,
- Tao Liu,
- Tao Liu,
- Jiangxue Qu,
- Jiangxue Qu,
- Jiangxue Qu,
- Jiangxue Qu,
- Jiangxue Qu,
- Mengyuan Tian,
- Mengyuan Tian,
- Mengyuan Tian,
- Mengyuan Tian,
- Mengyuan Tian,
- Rui Yang,
- Rui Yang,
- Rui Yang,
- Rui Yang,
- Rui Yang,
- Xueling Song,
- Xueling Song,
- Xueling Song,
- Xueling Song,
- Xueling Song,
- Rong Li,
- Rong Li,
- Rong Li,
- Rong Li,
- Rong Li,
- Jie Yan,
- Jie Yan,
- Jie Yan,
- Jie Yan,
- Jie Yan,
- Jie Qiao,
- Jie Qiao,
- Jie Qiao,
- Jie Qiao,
- Jie Qiao
Affiliations
- Tao Liu
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Tao Liu
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Tao Liu
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Tao Liu
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Tao Liu
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jiangxue Qu
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jiangxue Qu
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jiangxue Qu
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jiangxue Qu
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jiangxue Qu
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Mengyuan Tian
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Mengyuan Tian
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Mengyuan Tian
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Mengyuan Tian
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Mengyuan Tian
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Rui Yang
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Rui Yang
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Rui Yang
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Rui Yang
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Rui Yang
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Xueling Song
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Xueling Song
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Xueling Song
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Xueling Song
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Xueling Song
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Rong Li
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Rong Li
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Rong Li
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Rong Li
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Rong Li
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jie Yan
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jie Yan
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jie Yan
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jie Yan
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jie Yan
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- Jie Qiao
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
- Jie Qiao
- National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
- Jie Qiao
- Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China
- Jie Qiao
- Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China
- Jie Qiao
- Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China
- DOI
- https://doi.org/10.3389/fcell.2022.806890
- Journal volume & issue
-
Vol. 10
Abstract
Oocyte maturation is a complex and dynamic process regulated by the coordination of ovarian cells and numerous extraovarian signals. From mammal studies, it is learnt that lipid metabolism provides sufficient energy for morphological and cellular events during folliculogenesis, and numerous lipid metabolites, including cholesterol, lipoproteins, and 14-demethyl-14-dehydrolanosterol, act as steroid hormone precursors and meiotic resumption regulators. Endogenous and exogenous signals, such as gonadotropins, insulin, and cortisol, are the upstream regulators in follicular lipid metabolic homeostasis, forming a complex and dynamic network in which the key factor or pathway that plays the central role is still a mystery. Though lipid metabolites are indispensable, long-term exposure to a high-fat environment will induce irreversible damage to follicular cells and oocyte meiosis. This review specifically describes the transcriptional expression patterns of several lipid metabolism–related genes in human oocytes and granulosa cells during folliculogenesis, illustrating the spatiotemporal lipid metabolic changes in follicles and the role of lipid metabolism in female reproductive capacity. This study aims to elaborate the impact of lipid metabolism on folliculogenesis, thus providing guidance for improving the fertility of obese women and the clinical outcome of assisted reproduction.
Keywords
