EXPERIMENTAL STUDIES OF THE SPECIFICITY OF IMMUNE RESPONSE IN VARIOUS OCCUPATIONAL DISEASES

D. V. Fomenko; N. N. Mikhailova; A. S. Kazitskya; E. V. Ulanova; Y. A. Prokopyev

Acta Biomedica Scientifica (Sep 2012)

EXPERIMENTAL STUDIES OF THE SPECIFICITY OF IMMUNE RESPONSE IN VARIOUS OCCUPATIONAL DISEASES

D. V. Fomenko,
N. N. Mikhailova,
A. S. Kazitskya,
E. V. Ulanova,
Y. A. Prokopyev

Affiliations

D. V. Fomenko: Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS
N. N. Mikhailova: Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS
A. S. Kazitskya: Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS
E. V. Ulanova: Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS
Y. A. Prokopyev: Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS

Journal volume & issue: Vol. 0, no. 5(2)
pp. 115 – 119

Abstract

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Experimental models of anthracosilicosis (AS) and fluoride intoxication. (FI) show that the inhalation of coal and. rock dust (CRD) results in an early anti-inflammatory cytokine response (IL-4, IL-10) and. activation of humoral immunity on the background of lower level of proinflammatory cytokines. Later stages of the CRD activity are characterized by inflammation and. immunodeficiency. FI start is accompanied, by an increase of proinflammatory cytokines (IL-8, TNF-α). Anti-inflammatory protection is seen on the later stages (IL-10), immunoglobulin levels did. not change during 6 weeks of FI. Recommendations for the prevention of the anthracosilicosis and. fluoride intoxication given.

Published in Acta Biomedica Scientifica

ISSN: 2541-9420 (Print); 2587-9596 (Online)
Publisher: Scientific Сentre for Family Health and Human Reproduction Problems
Country of publisher: Russian Federation
LCC subjects: Science
Website: http://actabiomedica.ru/en/

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Abstract

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