Journal of International Medical Research (Dec 2018)

The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus

  • Toshihiro Higashikawa,
  • Tomohiko Ito,
  • Takurou Mizuno,
  • Keiichirou Ishigami,
  • Masaru Kohori,
  • Kunihiro Mae,
  • Ryusho Sangen,
  • Daisuke Usuda,
  • Atsushi Saito,
  • Masaharu Iguchi,
  • Yuji Kasamaki,
  • Akihiro Fukuda,
  • Hitoshi Saito,
  • Tsugiyasu Kanda,
  • Masashi Okuro

DOI
https://doi.org/10.1177/0300060518790870
Journal volume & issue
Vol. 46

Abstract

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Objective To assess the effect of 12 months of treatment with tofogliflozin on electrolytes and dehydration in Japanese patients with type 2 diabetes mellitus (T2DM) Methods This retrospective study involved mainly elderly patients with T2DM who had received tofogliflozin for 12 months. Data on glycated haemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride), haematocrit, estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN)/creatinine ratio were retrieved and analysed. Results Data from 69 patients (77% of whom were ≥65 years) showed that there was a significant reduction in HbA1c over the 12-month treatment period with tofogliflozin. However, the drug had no significant effect on levels of haematocrit, electrolytes, eGFR or BUN/creatinine ratio. Conclusion This retrospective analysis of data from mainly elderly Japanese patients with T2DM showed that 12-month administration of tofogliflozin exhibited glucose-lowering capabilities with accompanying low risk of electrolyte abnormalities and dehydration.