MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures

Benjamin Gottschalk; Zhanat Koshenov; Markus Waldeck-Weiermair; Snježana Radulović; Furkan E. Oflaz; Martin Hirtl; Olaf A. Bachkoenig; Gerd Leitinger; Roland Malli; Wolfgang F. Graier

doi:10.1038/s42003-022-03606-3

Communications Biology (Jul 2022)

MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures

Benjamin Gottschalk,
Zhanat Koshenov,
Markus Waldeck-Weiermair,
Snježana Radulović,
Furkan E. Oflaz,
Martin Hirtl,
Olaf A. Bachkoenig,
Gerd Leitinger,
Roland Malli,
Wolfgang F. Graier

Affiliations

Benjamin Gottschalk: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Zhanat Koshenov: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Markus Waldeck-Weiermair: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Snježana Radulović: Gottfried Schatz Research Center: Cell Biology, Histology and Embryology, Medical University of Graz
Furkan E. Oflaz: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Martin Hirtl: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Olaf A. Bachkoenig: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Gerd Leitinger: Gottfried Schatz Research Center: Cell Biology, Histology and Embryology, Medical University of Graz
Roland Malli: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz
Wolfgang F. Graier: Gottfried Schatz Research Center: Molecular Biology and Biochemistry, Medical University of Graz

DOI: https://doi.org/10.1038/s42003-022-03606-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Within mitochondrial substructures, MICU1 is shown to mediate Ca2+ control over spatial membrane potential gradients (SMPGs), with alterations in SMPGs following Ca2+ binding to MICU1 resulting in spatial cristae depolarization.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal