MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

Pei Li; Yang Yang; Hui Liu; An-Kui Yang; Jin-Ming Di; Guang-Mou Tan; Hai-Feng Wang; Jian-Ge Qiu; Wen-Ji Zhang; Qi-Wei Jiang; Di-Wei Zheng; Yao Chen; Meng-Ning Wei; Jia-Rong Huang; Kun Wang; Zhi Shi; Jin Ye

doi:10.1186/s13045-017-0402-6

Journal of Hematology & Oncology (Jan 2017)

MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

Pei Li,
Yang Yang,
Hui Liu,
An-Kui Yang,
Jin-Ming Di,
Guang-Mou Tan,
Hai-Feng Wang,
Jian-Ge Qiu,
Wen-Ji Zhang,
Qi-Wei Jiang,
Di-Wei Zheng,
Yao Chen,
Meng-Ning Wei,
Jia-Rong Huang,
Kun Wang,
Zhi Shi,
Jin Ye

Affiliations

Pei Li: Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University
Yang Yang: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Hui Liu: Division of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat-sen University
An-Kui Yang: Department of Head and Neck, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Jin-Ming Di: Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University
Guang-Mou Tan: Department of Head & Neck Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Hai-Feng Wang: Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University
Jian-Ge Qiu: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Wen-Ji Zhang: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Qi-Wei Jiang: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Di-Wei Zheng: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Yao Chen: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Meng-Ning Wei: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Jia-Rong Huang: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Kun Wang: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Zhi Shi: Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University
Jin Ye: Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University

DOI: https://doi.org/10.1186/s13045-017-0402-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 4

Abstract

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Abstract The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients.

Published in Journal of Hematology & Oncology

ISSN: 1756-8722 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://jhoonline.biomedcentral.com/

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