Progression of respiratory disorders associated with Parkinson's disease

Abstract

Parkinson's disease (PD), a common degenerative disease of the central nervous system, can affect the respiratory system. Pulmonary complications remain its leading cause of death, but the pathogenesis and its relationship to the severity of motor symptoms and non⁃motor symptoms, medication, and disease phenotype in PD have not been fully elucidated. This article reviews the advances in research on the anatomical and physiological basis, the disease itself and treatment⁃related respiratory disturbances to deepen the understanding of respiratory dysfunction associated with PD and to provide new insights for treatment.

Keywords

• parkinson disease
• respiration disorders
• levodopa
• deep brain stimulation
• review