Nature Communications (Nov 2021)
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
- Christina Kyrousi,
- Adam C. O’Neill,
- Agnieska Brazovskaja,
- Zhisong He,
- Pavel Kielkowski,
- Laure Coquand,
- Rossella Di Giaimo,
- Pierpaolo D’ Andrea,
- Alexander Belka,
- Andrea Forero Echeverry,
- Davide Mei,
- Matteo Lenge,
- Cristiana Cruceanu,
- Isabel Y. Buchsbaum,
- Shahryar Khattak,
- Guimiot Fabien,
- Elisabeth Binder,
- Frances Elmslie,
- Renzo Guerrini,
- Alexandre D. Baffet,
- Stephan A. Sieber,
- Barbara Treutlein,
- Stephen P. Robertson,
- Silvia Cappello
Affiliations
- Christina Kyrousi
- Max Planck Institute of Psychiatry
- Adam C. O’Neill
- Department of Women’s and Children’s Health, University of Otago
- Agnieska Brazovskaja
- Max Planck Institute for Evolutionary Anthropology
- Zhisong He
- Max Planck Institute for Evolutionary Anthropology
- Pavel Kielkowski
- Department of Chemistry, Chair of Organic Chemistry II, Center for Integrated Protein Science (CIPSM), Technische Universität München
- Laure Coquand
- Institut Curie, PSL Research University, CNRS, UMR 144, 26 rue d’Ulm
- Rossella Di Giaimo
- Max Planck Institute of Psychiatry
- Pierpaolo D’ Andrea
- Max Planck Institute of Psychiatry
- Alexander Belka
- Max Planck Institute of Psychiatry
- Andrea Forero Echeverry
- Max Planck Institute of Psychiatry
- Davide Mei
- Neuroscience Department, Children’s Hospital A. Meyer-University of Florence
- Matteo Lenge
- Neuroscience Department, Children’s Hospital A. Meyer-University of Florence
- Cristiana Cruceanu
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Isabel Y. Buchsbaum
- Max Planck Institute of Psychiatry
- Shahryar Khattak
- DFG-Research Center and Cluster of Excellence for Regenerative Therapies (CRTD), School of Medicine, Technical University Dresden
- Guimiot Fabien
- Unité de Foetopathologie, Assistance Publique-Hôpitaux de Paris, CHU Robert Debré
- Elisabeth Binder
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Frances Elmslie
- South West Thames Regional Genetics Service, St George’s, University of London
- Renzo Guerrini
- Neuroscience Department, Children’s Hospital A. Meyer-University of Florence
- Alexandre D. Baffet
- Institut Curie, PSL Research University, CNRS, UMR 144, 26 rue d’Ulm
- Stephan A. Sieber
- Department of Chemistry, Chair of Organic Chemistry II, Center for Integrated Protein Science (CIPSM), Technische Universität München
- Barbara Treutlein
- Max Planck Institute for Evolutionary Anthropology
- Stephen P. Robertson
- Department of Women’s and Children’s Health, University of Otago
- Silvia Cappello
- Max Planck Institute of Psychiatry
- DOI
- https://doi.org/10.1038/s41467-021-26447-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neural progenitor position in organoids, human fetal tissue and mice.
