PU.1 and Haematopoietic Cell Fate: Dosage Matters

Ka Sin Mak; Alister P. W. Funnell; Richard C. M. Pearson; Merlin Crossley

doi:10.1155/2011/808524

International Journal of Cell Biology (Jan 2011)

PU.1 and Haematopoietic Cell Fate: Dosage Matters

Ka Sin Mak,
Alister P. W. Funnell,
Richard C. M. Pearson,
Merlin Crossley

Affiliations

Ka Sin Mak: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Alister P. W. Funnell: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Richard C. M. Pearson: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Merlin Crossley: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia

DOI: https://doi.org/10.1155/2011/808524
Journal volume & issue: Vol. 2011

Abstract

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The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis.

Published in International Journal of Cell Biology

ISSN: 1687-8876 (Print); 1687-8884 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/3531

About the journal