MicroRNAs as biomarkers in induced metabolic syndrome in rats

Abstract

Metabolic syndrome (Mets), consists of many clinical changes, such as dyslipidemia, obesity, resistance to insulin, and oxidative stress. It is become a global epidemic health problem. In recent years, microRNAs used as biomarkers have been critical in regulating this pathophysiological prominence, and their diagnosis and therapy. This study analyzes the purpose of miRNAs function in metabolic syndrome via focusing on the miR- 122 and miR- 126, which act as an essential key element in regulating thehomeostasis of lipids by controlling the lipoprotein generation and cholesterol synthesis in the liver. Twenty-one rats, 2.5 months old, were randomly split into 3 groups: the control group was were given standard diet and tap water, the second group: was treated with 40% fructose for 15 days, and the third group: was treated with 40% fructose daily for 30 days. miR-122 level was most significantly elevated (with a 40.12-fold change) in the third group. Meanwhile, miR-126 was unregulated in the second group with an 18.20-fold change. This indicates that miR-122 irregularities are affected in the progression of diabetes mellitus type 2 by inducing hyperglycemia, dyslipidemia, and insulin resistance. It can be concluded that circulating microRNAs were principally associated with glucose, lipid metabolism, metabolic syndrome, immunological function, inflammatory diseases, and malignancy disorders.

Keywords

• high fructose diet
• micrornas
• metabolic syndrome
• mir-122
• mir-126