MOLECULAR BIOMARKERS FOR DIAGNOSTICS, RISK STRATIFICATION AND PREDICTION OF CHRONIC HEART FAILURE

Abstract

Classic presentation of congestive heart failure do not have enough sensitivity and specificity, which lead to delayed diagnostics and worsening of the disease outcome. The concept of molecular biomarkers received broad development during past decade. Recently, a range of biomarkers has been invented, representing different pathopgysiological processes of chronic heart failure pathogenesis. These are reliable, safe and objective tool for diagnostics and stratification of adverse events risk, which adds to clinical and instrumental data and reflects the specifics of development and progression mechanisms in an exact patient. The review focuses on a synthesis of known evidence data on the role of biomarkers in diagnostics and risk stratification.

Keywords

• chronic heart failure
• biomarkers
• myocardial stress
• fibrosis
• prognosis
• diagnostics