Gold Nanoparticles and Graphene Oxide Flakes Synergistic Partaking in Cytosolic Bactericidal Augmentation: Role of ROS and NOX2 Activity

Osamah Al Rugaie; Majid Jabir; Rua Kadhim; Esraa Karsh; Ghassan M. Sulaiman; Salman A. A. Mohammed; Riaz A. Khan; Hamdoon A. Mohammed

doi:10.3390/microorganisms9010101

Microorganisms (Jan 2021)

Gold Nanoparticles and Graphene Oxide Flakes Synergistic Partaking in Cytosolic Bactericidal Augmentation: Role of ROS and NOX2 Activity

Osamah Al Rugaie,
Majid Jabir,
Rua Kadhim,
Esraa Karsh,
Ghassan M. Sulaiman,
Salman A. A. Mohammed,
Riaz A. Khan,
Hamdoon A. Mohammed

Affiliations

Osamah Al Rugaie: Department of Basic Medical Sciences, College of Medicine and Medical Sciences, Qassim University, Unaizah, P.O. Box 991, Al-Qassim 51911, Saudi Arabia
Majid Jabir: Department of Applied Sciences, Division of Biotechnology, University of Technology, Baghdad 35010, Iraq
Rua Kadhim: Department of Applied Sciences, Division of Biotechnology, University of Technology, Baghdad 35010, Iraq
Esraa Karsh: Department of Applied Sciences, Division of Biotechnology, University of Technology, Baghdad 35010, Iraq
Ghassan M. Sulaiman: Department of Applied Sciences, Division of Biotechnology, University of Technology, Baghdad 35010, Iraq
Salman A. A. Mohammed: Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia
Riaz A. Khan: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia
Hamdoon A. Mohammed: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia

DOI: https://doi.org/10.3390/microorganisms9010101
Journal volume & issue: Vol. 9, no. 1
p. 101

Abstract

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Gold nanoparticles (GNPs) and graphene oxide flakes (GOFs) exerted significantly (p Staphylococcus aureus and Escherichia coli. Under experimental conditions, upon bacterial exposure, the combined GNPs and GOFs induced significant clearance of bacteria through phagosome maturation (p p p p p < 0.0001). The current study demonstrated that GNPs’ and GOFs’ bactericidal assisting potentials could be considered an effective and alternative strategy for treating infections from both positive and negative bacterial strains.

Published in Microorganisms

ISSN: 2076-2607 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.mdpi.com/journal/microorganisms

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