Gut microbes in central nervous system development and related disorders

Yumeng Gan; Yumeng Gan; Yao Chen; Yao Chen; Huijie Zhong; Huijie Zhong; Huijie Zhong; Zhuo Liu; Zhuo Liu; Jiawei Geng; Jiawei Geng; Jiawei Geng; Huishan Wang; Wenxue Wang; Wenxue Wang; Wenxue Wang; Wenxue Wang

doi:10.3389/fimmu.2023.1288256

Frontiers in Immunology (Jan 2024)

Gut microbes in central nervous system development and related disorders

Yumeng Gan,
Yumeng Gan,
Yao Chen,
Yao Chen,
Huijie Zhong,
Huijie Zhong,
Huijie Zhong,
Zhuo Liu,
Zhuo Liu,
Jiawei Geng,
Jiawei Geng,
Jiawei Geng,
Huishan Wang,
Wenxue Wang,
Wenxue Wang,
Wenxue Wang,
Wenxue Wang

Affiliations

Yumeng Gan: Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
Yumeng Gan: School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
Yao Chen: Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
Yao Chen: School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
Huijie Zhong: Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
Huijie Zhong: School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
Huijie Zhong: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Zhuo Liu: Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
Zhuo Liu: School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
Jiawei Geng: Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
Jiawei Geng: School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
Jiawei Geng: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China
Huishan Wang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Wenxue Wang: Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
Wenxue Wang: School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China
Wenxue Wang: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China
Wenxue Wang: School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, China

DOI: https://doi.org/10.3389/fimmu.2023.1288256
Journal volume & issue: Vol. 14

Abstract

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The association between gut microbiota and central nervous system (CNS) development has garnered significant research attention in recent years. Evidence suggests bidirectional communication between the CNS and gut microbiota through the brain-gut axis. As a long and complex process, CNS development is highly susceptible to both endogenous and exogenous factors. The gut microbiota impacts the CNS by regulating neurogenesis, myelination, glial cell function, synaptic pruning, and blood-brain barrier permeability, with implication in various CNS disorders. This review outlines the relationship between gut microbiota and stages of CNS development (prenatal and postnatal), emphasizing the integral role of gut microbes. Furthermore, the review explores the implications of gut microbiota in neurodevelopmental disorders, such as autism spectrum disorder, Rett syndrome, and Angelman syndrome, offering insights into early detection, prompt intervention, and innovative treatments.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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