Nature Communications (Nov 2020)
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
- Deli Huang,
- Jenny Tuyet Tran,
- Alex Olson,
- Thomas Vollbrecht,
- Mary Tenuta,
- Mariia V. Guryleva,
- Roberta P. Fuller,
- Torben Schiffner,
- Justin R. Abadejos,
- Lauren Couvrette,
- Tanya R. Blane,
- Karen Saye,
- Wenjuan Li,
- Elise Landais,
- Alicia Gonzalez-Martin,
- William Schief,
- Ben Murrell,
- Dennis R. Burton,
- David Nemazee,
- James E. Voss
Affiliations
- Deli Huang
- Department of Immunology and Microbiology, The Scripps Research Institute
- Jenny Tuyet Tran
- Department of Immunology and Microbiology, The Scripps Research Institute
- Alex Olson
- Department of Immunology and Microbiology, The Scripps Research Institute
- Thomas Vollbrecht
- Department of Medicine, The University of California San Diego
- Mary Tenuta
- Department of Immunology and Microbiology, The Scripps Research Institute
- Mariia V. Guryleva
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet
- Roberta P. Fuller
- Department of Immunology and Microbiology, The Scripps Research Institute
- Torben Schiffner
- Department of Immunology and Microbiology, The Scripps Research Institute
- Justin R. Abadejos
- Department of Immunology and Microbiology, The Scripps Research Institute
- Lauren Couvrette
- Department of Immunology and Microbiology, The Scripps Research Institute
- Tanya R. Blane
- Department of Immunology and Microbiology, The Scripps Research Institute
- Karen Saye
- Department of Immunology and Microbiology, The Scripps Research Institute
- Wenjuan Li
- Department of Immunology and Microbiology, The Scripps Research Institute
- Elise Landais
- Department of Immunology and Microbiology, The Scripps Research Institute
- Alicia Gonzalez-Martin
- Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM)
- William Schief
- Department of Immunology and Microbiology, The Scripps Research Institute
- Ben Murrell
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- David Nemazee
- Department of Immunology and Microbiology, The Scripps Research Institute
- James E. Voss
- Department of Immunology and Microbiology, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-19650-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
A vaccine to generate durable HIV broadly neutralizing antibodies (bnAb) from engineered B cells holds promise as an HIV functional cure. Here, the authors show that CRISPR/Cas-modified B cells expressing bnAbs as functional antigen receptors can be immunized to generate long-lived, germinal centre matured bnAb memory and plasma cells in mice.
