Frontiers in Neurology (Oct 2021)
Association Between CST3 Gene Polymorphisms and Large-Artery Atherosclerotic Stroke
- Yarong Ding,
- Yarong Ding,
- Yarong Ding,
- Yarong Ding,
- Zhe Xu,
- Zhe Xu,
- Zhe Xu,
- Zhe Xu,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Xianglong Xiang,
- Xianglong Xiang,
- Xianglong Xiang,
- Xianglong Xiang,
- Hao Li,
- Hao Li,
- Hao Li,
- Hao Li,
- Liping Liu,
- Liping Liu,
- Liping Liu,
- Liping Liu,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang
Affiliations
- Yarong Ding
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yarong Ding
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yarong Ding
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yarong Ding
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Zhe Xu
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Zhe Xu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Zhe Xu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Zhe Xu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yuesong Pan
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yuesong Pan
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yuesong Pan
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yuesong Pan
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xia Meng
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xia Meng
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xia Meng
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xia Meng
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xianglong Xiang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xianglong Xiang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xianglong Xiang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xianglong Xiang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Hao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Hao Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Hao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Hao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Liping Liu
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Liping Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Liping Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Liping Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yongjun Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yongjun Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yongjun Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yongjun Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- DOI
- https://doi.org/10.3389/fneur.2021.738148
- Journal volume & issue
-
Vol. 12
Abstract
Objective: Cystatin C, a marker of atherosclerosis, is encoded by CST3. We aimed to evaluate whether two single-nucleotide polymorphisms (SNPs) of CST3 are correlated with large-artery atherosclerotic stroke (LAAS) and prognosis.Methods: This subgroup analysis of the Third China National Stroke Registry (CNSR-III) enrolled acute ischemic stroke (AIS) patients within 7 days from August 2015 to March 2018 in China. rs13038305 and rs911119 of CST3 were selected based on the strong association with cystatin C concentration.Results: Two loci of CST3 (rs13038305 and rs911119) were analyzed in 3,833 ischemic stroke patients. Carriers of T allele in rs13038305 and C allele in rs911119 tend to have lower serum cystatin C levels (p < 0.05). Compared with C/C as a reference in rs13038305, odds ratio (OR) of T/T was 0.486, 95% CI 0.237–0.994, p = 0.048. Per C allele of rs13038305 also showed an increased level of low-density lipoprotein cholesterol (LDL-C), β (95% CI) was 1.335 (1.008–1.250), p = 0.044. No correlation was found between the selected SNPs and stroke prognosis (functional outcome, recurrence, and mortality).Conclusions: Carriers of the T allele in rs13038305 tend to have a lower proportion of LAAS. rs13038305 and rs911119 polymorphisms were likely to affect cystatin C concentration independently of kidney function.
Keywords
