Nature Communications (Feb 2021)
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
- Anders B. Klein,
- Trine S. Nicolaisen,
- Niels Ørtenblad,
- Kasper D. Gejl,
- Rasmus Jensen,
- Andreas M. Fritzen,
- Emil L. Larsen,
- Kristian Karstoft,
- Henrik E. Poulsen,
- Thomas Morville,
- Ronni E. Sahl,
- Jørn W. Helge,
- Jens Lund,
- Sarah Falk,
- Mark Lyngbæk,
- Helga Ellingsgaard,
- Bente K. Pedersen,
- Wei Lu,
- Brian Finan,
- Sebastian B. Jørgensen,
- Randy J. Seeley,
- Maximilian Kleinert,
- Bente Kiens,
- Erik A. Richter,
- Christoffer Clemmensen
Affiliations
- Anders B. Klein
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Trine S. Nicolaisen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Niels Ørtenblad
- Department of Sports Science and Clinical Biomechanics, University of Southern Denmark
- Kasper D. Gejl
- Department of Sports Science and Clinical Biomechanics, University of Southern Denmark
- Rasmus Jensen
- Department of Sports Science and Clinical Biomechanics, University of Southern Denmark
- Andreas M. Fritzen
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Emil L. Larsen
- Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen
- Kristian Karstoft
- Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen
- Henrik E. Poulsen
- Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen
- Thomas Morville
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Ronni E. Sahl
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Jørn W. Helge
- Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen
- Jens Lund
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Sarah Falk
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Mark Lyngbæk
- Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen
- Helga Ellingsgaard
- Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen
- Bente K. Pedersen
- Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen
- Wei Lu
- Novo Nordisk Research Center Indianapolis
- Brian Finan
- Novo Nordisk Research Center Indianapolis
- Sebastian B. Jørgensen
- Global Obesity and LD Research, Novo Nordisk A/S
- Randy J. Seeley
- Department of Surgery, University of Michigan
- Maximilian Kleinert
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Bente Kiens
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Erik A. Richter
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Christoffer Clemmensen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-021-21309-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 9
Abstract
The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food intake or exercise motivation.
