The evaluation of С-terminal telopeptide of type-i collagen level in patients with chronic heart failure along with atrial fibrillation and postinfarction cardiosclerosis

Abstract

C-terminal telopeptide of type-I collagen level was studied in 112 chronic heart failure (CHF) patients and in 30 patients without heart failure. As a result, in CHF patients with atrial fibrillation compared to patients with sinus rhythm increase of C-terminal telopeptide of type-I collagen level was revealed. Increase of C-terminal telopeptide of type-I collagen level was also revealed in CHF patients with postinfarction cardiosclerosis compared to patients with no myocardial infarctions history; it reflects the association of maladaptive remodeling of the myocardium in postinfarction cardiosclerosis with intensification of extracellular matrix disorganization and disintegration of interstitial collagen processes.

Keywords

• хроническая сердечная недостаточность
• с-концевой телопептид коллагена i типа
• фибрилляция предсердий
• постинфарктный кардиосклероз
• chronic heart failure
• c-terminal telopeptide of type-i collagen
• atrial fibrillation
• postinfarction cardiosclerosis