Prosthetic heart valves for transcatheter aortic valve replacement
Xinman Hu,
Shifen Li,
Pai Peng,
Beiduo Wang,
Wenxing Liu,
Xiaofei Dong,
Xiayan Yang,
Miroslav Karabaliev,
Qifeng Yu,
Changyou Gao
Affiliations
Xinman Hu
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Shifen Li
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Pai Peng
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Beiduo Wang
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Wenxing Liu
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Xiaofei Dong
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Xiayan Yang
Shanghai NewMed Medical Technology Co., Ltd Shanghai China
Miroslav Karabaliev
Department of Medical Physics, Biophysics and Radiology Faculty of Medicine Trakia University Stara Zagora Bulgaria
Qifeng Yu
Shanghai NewMed Medical Technology Co., Ltd Shanghai China
Changyou Gao
MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for Functional Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou China
Abstract Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aortic valve replacement (SAVR). The interventional valve used in TAVR needs to be compressed and transported through the catheter to the lesion site, and can still recover its original shape, structure and performance. This process requires that the material should be flexible, and the rigid mechanical valves in SAVR are not suitable. Recently, decellularized biological valves have been widely used in clinical practice, but their poor durability causes a limitation for long‐term implantation. Therefore, the anti‐calcification modification of biological valves and the design of new polymeric valves with good biostability have gained considerable attention. This review summarizes the calcification mechanism of biological valves and the research progress in anti‐calcification modification strategies. Besides, the development of new polymeric valves is included, with special attention to representative cases, such as polysiloxane, polytetrafluorethylene, poly(styrene‐block‐isobutylene‐block‐styrene), and polyurethane‐based materials. Finally, the challenges and future perspectives of artificial heart valve materials are discussed.
