Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in Patients with Chronic Kidney Disease
Apostolos Sovatzidis,
Athanasios Chatzinikolaou,
Ioannis G. Fatouros,
Stylianos Panagoutsos,
Dimitrios Draganidis,
Eirini Nikolaidou,
Alexandra Avloniti,
Yiannis Michailidis,
Ioannis Mantzouridis,
Alexios Batrakoulis,
Ploumis Pasadakis,
Vassilis Vargemezis
Affiliations
Apostolos Sovatzidis
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Athanasios Chatzinikolaou
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece
Ioannis G. Fatouros
School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece
Stylianos Panagoutsos
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Dimitrios Draganidis
School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece
Eirini Nikolaidou
Department of Plastic, Reconstructive and Hand Surgery & Burns ICU, General Hospital of Thessaloniki “G. Papanikolaou”, 57010 Thessaloniki, Greece
Alexandra Avloniti
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece
Yiannis Michailidis
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece
Ioannis Mantzouridis
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece
Alexios Batrakoulis
School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece
Ploumis Pasadakis
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Redox status (RS) perturbations and inflammation are fundamental features of chronic kidney disease (CKD) that are substantially exacerbated in end-stage renal disease (ESRD). This study aimed at investigating the efficacy of a 6-month intradialytic exercise training program on RS, inflammation and physical performance in patients with ESRD. Twenty hemodialysis (HD) patients (17 males, three females) were randomly assigned to either an intradialytic training (bedside cycling) group (TR; n = 10) or a control group (CON; n = 10) for 6 months. Anthropometrics [body mass and height, body mass index (BMI), body composition], physical performance (VO2peak), functional capacity [North Staffordshire Royal Infirmary (NSRI) walk test, sit-to-stand test (STS-60)], quality of life (short form-36 (SF-36) as well as RS [thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), reduced (GSH) and oxidized (GSSG) glutathione, GSH/GSSG, total antioxidant capacity (TAC), catalase activity (CAT)] and high-sensitivity C-reactive protein (hs-CRP) were assessed at baseline and after the 6-month intervention. Peak oxygen consumption (VO2peak) increased by 15% only in TR (p p p < 0.01). These findings suggest that engagement in chronic intradialytic cardiovascular exercise alters RS, reduces inflammation and improves performance in patients with ESRD.
