Nature Communications (May 2018)
High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing
- Peng Zhang,
- Ji-Han Xia,
- Jing Zhu,
- Ping Gao,
- Yi-Jun Tian,
- Meijun Du,
- Yong-Chen Guo,
- Sufyan Suleman,
- Qin Zhang,
- Manish Kohli,
- Lori S. Tillmans,
- Stephen N. Thibodeau,
- Amy J. French,
- James R. Cerhan,
- Li-Dong Wang,
- Gong-Hong Wei,
- Liang Wang
Affiliations
- Peng Zhang
- Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University
- Ji-Han Xia
- Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Jing Zhu
- Department of Pathology, MCW Cancer Center, Medical College of Wisconsin
- Ping Gao
- Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Yi-Jun Tian
- Department of Pathology, MCW Cancer Center, Medical College of Wisconsin
- Meijun Du
- Department of Pathology, MCW Cancer Center, Medical College of Wisconsin
- Yong-Chen Guo
- Department of Pathology, MCW Cancer Center, Medical College of Wisconsin
- Sufyan Suleman
- Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Qin Zhang
- Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Manish Kohli
- Department of Oncology, Mayo Clinic
- Lori S. Tillmans
- Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW
- Stephen N. Thibodeau
- Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW
- Amy J. French
- Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW
- James R. Cerhan
- Department of Health Sciences Research, Mayo Clinic
- Li-Dong Wang
- Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University
- Gong-Hong Wei
- Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Liang Wang
- Department of Pathology, MCW Cancer Center, Medical College of Wisconsin
- DOI
- https://doi.org/10.1038/s41467-018-04451-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Functional characterization of disease-causing variants at risk loci in cancer is challenging. Here, in prostate cancer the authors report a pipeline for high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) for large scale screening of functional SNPs at disease risk loci.
