European Journal of Histochemistry (Jun 2018)

GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

  • Mário S. de Souza Albuquerque,
  • Antônio F. da Silva-filho,
  • Marina Ferraz Cordeiro,
  • Maria de Fátima Deodato de Souza,
  • Michael W.L. Quirino,
  • Luiza R. Amorim Lima,
  • Maira G. da Rocha Pitta,
  • Mario R. Martins,
  • Moacyr J.B. de Melo Rêgo

DOI
https://doi.org/10.4081/ejh.2018.2931
Journal volume & issue
Vol. 62, no. 2

Abstract

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Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.

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