Frontiers in Neuroscience (Jun 2024)

Research advances in huntingtin-associated protein 1 and its application prospects in diseases

  • Yongjiang Wu,
  • Yanfei Wang,
  • Yunchi Lu,
  • Junguo Yan,
  • Hongjun Zhao,
  • Riyun Yang,
  • Jingying Pan

DOI
https://doi.org/10.3389/fnins.2024.1402996
Journal volume & issue
Vol. 18

Abstract

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Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington’s disease, Alzheimer’s disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.

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