The influence of the ACTN3 R577X polymorphism in the responsiveness to post-activation jump performance enhancement in untrained young men

Abstract

We aimed to investigate the influence of the alpha-actinin-3 (ACTN3) R577X polymorphism on responsiveness to post-activation performance enhancement (PAPE) of countermovement jumps (CMJ) in untrained subjects. Sixteen untrained men were allocated to two groups according to their ACTN3 gene alleles: homozygous for the X allele (XX, n = 9) or homozygous for the R allele (RR, n = 7). CMJ height, mean power output and vertical force were determined twice (CMJ1 and CMJ2) in two conditions: control (CON) and potentiated (PAPE). In the CON condition, CMJ were performed before and after 15 min of rest. In the PAPE condition, CMJ were performed 15 min before and 4 min following five squats with a 5-repetition maximum (5RM) load. Different conditions were performed on separate days in a randomized order. For statistical analysis three-way ANOVAs were used to compare the differences between conditions (CON and PAPE), time (CMJ1 and CMJ2) and groups (XX and RR). The level of significance was set at p 0.05) in responsiveness to PAPE between groups (XX = -0.20 ± 1.6 cm and RR = -0.81 ± 2.7 cm). We conclude that ACTN3 gene polymorphisms does not influence responsiveness to PAPE.

Keywords

• Athletic Performance
• Exercise
• Genetic Polymorphism