Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272

Abstract

Three new polyketides, ketidocillinones A−C (1−3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1−3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL.

Keywords

• antarctica sponge-derived fungus
• <i>penicillium</i> sp.
• polyketides
• antibacterial activity