Association of Helicobacter pylori infection with lipid profiles: The Persian Gulf Healthy Heart Study

Abstract

Background: Helicobacter pylori (H.pylori) infection may contribute to the development of extra-gastrointestinal manifestations like cardiovascular diseases. Detection of Helicobacter pylori in Athrosclerotic plaques is a strong evidence for this association which may play a role in pathogenesis of atherosclerosis with classic cardiovascular risk factor such as hypertension and lipid profile. The aim of this study was to explore the influence of H. pylori infection on lipid profiles in a large community- based study. Material and Methods: A total of 1754 (50.8% Female & 49.2% male) subjects (age >25 years old) were selected randomely from Monica Healthy Heart Study project. H. pylori status was determined by IgG ELISA method. Subjects with titers > 30 Iu/ml were cansidered seropositive. Data were analazed by using statistical software Spss version 18 and probability values 0.05) Conclusion: According to this large – scale population- based study in large northern cities of Persian Gulf, there was no significant association between H.pylori IgG seropositivity and lipid profiles in both men and women.

Keywords

• Helicobacter pylori
• High- density lipoprotein cholesterol
• Atherosclerosis
• Lipid profile.