Research Progress of Ocular Glymphatic System and Related Ocular Diseases

Abstract

Recent discovered ocular glymphatic system, which is facilitated by aquaporin-4 (AQP4) and dependent on the exchange system of aqueous humor-tissue fluid in the perivascular space of retinal arterial and venous, ultimately acts as the role of expelling neurotoxic substances such as beta-amyloid out of the eye, has updated our knowledge of intraocular circulation. This paper reviews the composition and function of ocular glymphatic system, describes its specific circulatory paths in the physiological state and mechanism of impairment in the progression of glaucoma, optic disc edema, Terson syndrome and other diseases, In the future, we can identify the specific regulatory links of the ocular glymphatic system and improve the function of the system, such as using the advantages of multiple targets and multiple pathways of traditional Chinese medicine to promote the removal of metabolic wastes in the eye, which will bring hope to the treatment of many eye diseases such as glaucoma and some central nervous system diseases.

Keywords

• glymphatic system|ocular glymphatic system|glaucoma|optic disk edema|terson syndrome|review