Nature Communications (May 2018)
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
- Yibing Wang,
- Liqin Cao,
- Chia-Ying Lee,
- Tomohiko Matsuo,
- Kejia Wu,
- Greg Asher,
- Lijun Tang,
- Tsuyoshi Saitoh,
- Jamie Russell,
- Daniela Klewe-Nebenius,
- Li Wang,
- Shingo Soya,
- Emi Hasegawa,
- Yoan Chérasse,
- Jiamin Zhou,
- Yuwenbin Li,
- Tao Wang,
- Xiaowei Zhan,
- Chika Miyoshi,
- Yoko Irukayama,
- Jie Cao,
- Julian P. Meeks,
- Laurent Gautron,
- Zhiqiang Wang,
- Katsuyasu Sakurai,
- Hiromasa Funato,
- Takeshi Sakurai,
- Masashi Yanagisawa,
- Hiroshi Nagase,
- Reiko Kobayakawa,
- Ko Kobayakawa,
- Bruce Beutler,
- Qinghua Liu
Affiliations
- Yibing Wang
- National Institute of Biological Sciences
- Liqin Cao
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Chia-Ying Lee
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Tomohiko Matsuo
- Functional Neuroscience Lab, Kansai Medical University
- Kejia Wu
- National Institute of Biological Sciences
- Greg Asher
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Lijun Tang
- Functional Neuroscience Lab, Kansai Medical University
- Tsuyoshi Saitoh
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Jamie Russell
- Center for Genetics of Host Defense, University of Texas Southwestern Medical Center
- Daniela Klewe-Nebenius
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Li Wang
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Shingo Soya
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Emi Hasegawa
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Yoan Chérasse
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Jiamin Zhou
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Yuwenbin Li
- Department of Biochemistry, University of Texas Southwestern Medical Center
- Tao Wang
- Center for Genetics of Host Defense, University of Texas Southwestern Medical Center
- Xiaowei Zhan
- Center for Genetics of Host Defense, University of Texas Southwestern Medical Center
- Chika Miyoshi
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Yoko Irukayama
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Jie Cao
- Department of Neuroscience, University of Texas Southwestern Medical Center
- Julian P. Meeks
- Department of Neuroscience, University of Texas Southwestern Medical Center
- Laurent Gautron
- Department of Internal Medicine, University of Texas Southwestern Medical Center
- Zhiqiang Wang
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Katsuyasu Sakurai
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Hiromasa Funato
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Takeshi Sakurai
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Masashi Yanagisawa
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Hiroshi Nagase
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Reiko Kobayakawa
- Functional Neuroscience Lab, Kansai Medical University
- Ko Kobayakawa
- Functional Neuroscience Lab, Kansai Medical University
- Bruce Beutler
- Center for Genetics of Host Defense, University of Texas Southwestern Medical Center
- Qinghua Liu
- National Institute of Biological Sciences
- DOI
- https://doi.org/10.1038/s41467-018-04324-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
TMT is a chemical that evokes innate defensive behaviors yet the molecular mechanisms are not well understood. Here the authors perform a large-scale forward genetics screen in mice and identify Trpa1, a pungency/irritancy receptor, as a chemosensor for predator odor-evoked innate fear and defensive behaviors.
