Molecules (May 2013)

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars

  • Chu-Yi Yu,
  • Yue-Mei Jia,
  • Jian-She Zhu,
  • Wen-Bo Zhao,
  • Hui Zhao

DOI
https://doi.org/10.3390/molecules18056021
Journal volume & issue
Vol. 18, no. 5
pp. 6021 – 6034

Abstract

Read online

D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of piperidine iminosugars.

Keywords