Nature Communications (May 2020)

nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

  • Hai-Ying Liang,
  • Zhi-Jin Chen,
  • Hui Xiao,
  • Yu-Hui Lin,
  • Ying-Yi Hu,
  • Lei Chang,
  • Hai-Yin Wu,
  • Peng Wang,
  • Wei Lu,
  • Dong-Ya Zhu,
  • Chun-Xia Luo

DOI
https://doi.org/10.1038/s41467-020-16198-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.